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Glycocyamine

Guanidinoacetic acid, also known as guanidinoacetate or glycocyamine, is not an amino acid, but has an effect on the metabolism of other canonical amino acids. Glycocyamine is a metabolic precursor of creatine. It is converted into creatine in the liver. As the intake of creatine inhibits the body's own creatine production, some researchers suspect that glycocyamine raises creatine levels more than creatine itself.

Advantages

Glycocyamine can improve the body's ability to produce creatine. Net effect corresponds to the creatine effect: weight gain and strength gain.

Dosage

The dosage is 2-3g spread over one or two doses per day. At the same time, you should take a methyl donor such as betaine (trimethylglycine), dimethylglicine (pangamic acid or vitamin B15) or SAMe (S-adenosyl-L-methionine) to stimulate creatine production and minimize the formation of homocysteine. But be careful! As homocysteine is an indicator of cardiovascular disease, people with cardiovascular disease should not use this product.

References

  1. Int J Dev Neurosci. 2003 Jun;21(4):183-9. Inhibition of Na+, K+-ATPase activity in rat striatum by guanidinoacetate. Zugno AI, Stefanello FM, Streck EL, Calcagnotto T, Wannmacher CM, Wajner M, Wyse AT.
  2. J Cereb Blood Flow Metab. 2002 Nov;22(11):1327-35. The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T.