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Evodiamine

Evodiamine is taken from a plant called Evodiae Fructus. This is a Chinese herb called Wu-Chu-Yu and has been used for centuries by Chinese natural healers to reduce weight. No known human studies have been published to date. Based on studies done in laboratories with localized cells and rodents, evodiamine may raise body temperature, inhibit the growth and metastasis of certain cancer cells in vitro, affect the metabolism of certain drugs, and affect the secretion of benzcatechinamines from the adrenal glands. Evodiamine reduces fat storage and increases the natural rate of fat burning.

Recent scientific studies have supported these findings. Mammals fed a high-fat diet while taking evodiamine actually lost weight instead of gaining it. This herbal extract is a mild, yet remarkable stimulant that has shown positive energy and diuretic properties. Even more exciting is its unique ability to significantly increase body heat production and keep the body's core temperature stable! This thermogenic effect can lead to an increase in calories and fat burned for energy. Evodiamine could be one of the biggest breakthroughs in thermogenesis. Since there have been no human studies, the recommended dosage cannot be determined. Follow the instructions for each product.

Safety and side effects

There is not enough information to make a statement about the safety and harmlessness of Evodiamine or about possible side effects.

Precautions and warnings

Pregnancy and lactation: Evodiamine may not be safe to use during pregnancy. Evodiamine contains some chemicals that may affect pregnancy in animals. These chemicals can cause contractions of the uterus in animals and reduce the size of the litter. It is not known if Evodiamine has similar effects in pregnant women, but it is best to err on the side of caution and not use Evodiamine during pregnancy. It is also best to avoid evodiamine while breastfeeding, as not enough is known about its effects. Surgeries: Evodiamine products could slow down blood clotting. There are concerns that this could increase the risk of bleeding during and after surgery. For this reason, the use of Evodiamine products should be stopped at least 2 weeks before planned operations.

Interactions

Care should be taken when combining Evodiamine with the following medications:

Caffeine

The body breaks down caffeine in order to excrete it. Evodiamine may accelerate the rate at which the body breaks down caffeine. Taking evodiamine in combination with caffeine could reduce the effectiveness of caffeine.

Drugs that are broken down by the liver (cytochrome P450 1A2 (CYP1A2) substrates)

Some drugs are broken down by the liver. Evodiamine may accelerate the rate at which the liver breaks down certain drugs. Taking evodiamine in conjunction with drugs that are broken down by the liver may reduce the effects of some drugs. For this reason, you should consult your doctor before taking evodiamine if you are taking medicines that are broken down by the liver.

Drugs that are broken down by the liver (cytochrome P450 3A4 (CYP3A4) substrates)

Some drugs are broken down by the liver. Evodiamine can reduce the rate at which the liver breaks down certain medicines. Taking evodiamine in combination with drugs that are broken down by the liver may increase the effects and side effects of some drugs. For this reason, you should consult your doctor before taking Evodiamine if you are taking medicines that are broken down by the liver.

Drugs that can reduce the breakdown of other drugs by the liver (cytochrome P450 1A2 (CYP1A2) inhibitors)

Some drugs are broken down by the liver. Some drugs can reduce the rate at which the liver breaks down evodiamine. Taking Evodiamine with some medicines that can slow down the breakdown of other medicines by the liver may increase the effects and side effects of Evodiamine.

Medications that slow down blood clotting

Evodiamine may slow down blood clotting. Taking Evodiamine in conjunction with medications that also slow blood clotting could increase the risk of bleeding and the tendency to bruise. Some medications that can slow blood clotting include aspirin, diclofenac (Voltaren), ibuprofen, naproxen and others.

Theophylline

The body breaks down theophylline in order to excrete it. Evodiamine may accelerate the rate at which the body breaks down theophylline. Taking evodiamine in combination with theophylline could reduce the effectiveness of theophylline.

References

  1. Soo Youn Chung, Sook Young Yi, Tae Moo Yoo, Mee Ryung Aim, Hyun Jin Choi, Myeon Woo Chung, Hang Mook Rheu, Ji Sun Yang. Studies on the Effects of Evodiae Fructus on the Cardiovascular System in N-nitro-L-arginine Methyl Ester-induced Hypertensive Wistar Rats. JOURNAL- PHARMACEUTICAL SOCIETY OF KOREA; ISSN: 0513-4242 1999; VOL 43; NUMBER 3; 397-403