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Diiodothyronine

Diiodothyronine is a hormone that is also known as T2 and is used as a medicine. Diiodothyronine is a naturally occurring metabolic product of the active thyroid hormones T3 and T4. Diiodothyronine is used to promote weight loss, treat high cholesterol levels and improve bodybuilding progress.

How does diiodothyronine work?

Some animal and test tube studies suggest that diiodothyronine may accelerate metabolic rate and reduce fat storage. However, there are no reliable human studies, so it is not known whether diiodothyronine has these effects in humans.

How effective is diiodothyronine?

There is insufficient scientific data to assess the effectiveness of diiodothyronine in promoting weight loss, lowering high cholesterol levels and improving bodybuilding results. Further scientific research is needed to evaluate the effectiveness of diiodothyronine in these applications.

Safety and side effects

There is not enough information to say whether diiodothyronine is safe and harmless or what side effects it may have.

Precautions and warnings

Pregnancy and lactation: Not enough is known about the use of diiodothyronine during pregnancy and lactation. For this reason, pregnant and breastfeeding women should avoid diiodothyronine.

Interactions

There is currently no information on interactions between diiodothyronine and medications or supplements.

Dosage

An appropriate dosage of diiodothyronine depends on various factors such as age, state of health and others. At the present time, there is insufficient scientific data to make a statement about appropriate dosage ranges for diiodothyronine. For this reason, you should follow the dosage instructions on the label and/or consult a doctor or pharmacist before use.

References

  1. Ball SG, Sokolov J, Chin WW. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol 1997;19:137-47.
  2. Giudetti AM, Leo M, Geelen MJ, Gnoni GV. Short-term stimulation of lipogenesis by 3,5-L-diiodothyronine in cultured rat hepatocytes. Endocrinology 2005;146:3959-66.
  3. Goglia F. Biological effects of 3,5-diiodothyronine (T(2)). Biochemistry (Mosc) 2005;70:164-72.
  4. Lanni A, Moreno M, Lombardi A, et al. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB J 2005;19:1552-4.
  5. Moreno M, Lombardi A, Lombardi P, et al. Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life Sci 1998;62:2369-77.
  6. Silvestri E, Schiavo L, Lombardi A, Goglia F. Thyroid hormones as molecular determinants of thermogenesis. Acta Physiol Scand 2005;184:265-83.