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Calcium D-glucarate

Calcium D-glucarate(calcium D-glucarate) is a chemical that is similar to the naturally occurring chemical glucaric acid. Glucaric acid occurs naturally in the human body and is also found in fruits and vegetables such as oranges, apples, Brussels sprouts, broccoli and cabbage. Calcium D-glucarate is produced by combining calcium with glucaric acid and is used as a supplement. Calcium D-glucarate is used to prevent breast, prostate and bowel cancer. Calcium D-glucarate is also said to remove carcinogenic substances, toxins and steroid hormones from the body.

How does calcium D-glucarate work?

CalciumD-glucarate may lower estrogen levels and is believed to be helpful in treating women suffering from hormone-dependent cancers. However, there is not enough scientific research to support the suggestion that calcium D-glucarate could prevent the development of cancer in humans.

How effective is calcium D-glucarate?

There is not enough scientific data to make a statement about the effectiveness of calcium D-glucarate in preventing breast, prostate and colon cancer, as well as in detoxifying the body from carcinogens, toxins and steroid hormones. Further scientific research is needed to evaluate the effectiveness of calcium D-glucarate in these areas of application.

Safety and side effects

There is not enough information to say whether calcium D-glucarate is safe and harmless or what side effects it may have.

Precautions and warnings

Pregnancy and lactation: Not enough is known about the use of calcium D-glucarate during pregnancy and lactation. For this reason, pregnant and breastfeeding women should avoid calcium D-glucarate.

Interactions

Care should be taken when using calcium D-glucarate in combination with the following medications:

Alcohol

The body breaks down calcium D-glucarate in order to be able to excrete it. Alcohol could accelerate the rate at which the body breaks down calcium D-glucarate and thereby reduce the effectiveness of calcium D-glucarate.

Drugs that are broken down by the liver (glucuronidated drugs)

The body breaks down some drugs via the liver in order to be able to excrete them. Calcium D-glucarate may accelerate the rate at which the liver breaks down certain drugs. Taking calcium D-glucarate in combination with these medications could reduce the effectiveness of these medications. Care should be taken when using calcium D-glucarate in combination with the following medications:

Kanamycin

Kanamycin is an antibiotic. The body breaks down kanamycin in order to be able to excrete it. Calcium D-glucarate could increase the rate at which the body breaks down kanamycin and thereby reduce the effectiveness of kanamycin.

Dosage

An appropriate dosage of calcium D-glucarate depends on various factors such as age, health status and others. At the present time, there is insufficient scientific data to make a statement about appropriate dosage ranges for calcium D-glucarate. For this reason, you should follow the dosage instructions on the label and/or consult a doctor or pharmacist before use.

References

  1. Curley RW Jr, Humphries KA, Koolemans-Beynan A, et al. Activity of D-glucarate analogues: synergistic antiproliferative effects with retinoid in cultured human mammary tumor cells appear to specifically require the D-glucarate structure. Life Sci 1994;54:1299-303.
  2. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  3. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3.
  4. Heerdt AS, Young CW, Borgen PI. Calcium glucarate as a chemopreventive agent in breast cancer. Isr J Med Sci 1995;31:101-5.
  5. Kampf D, Roots I, Hildenbrandt AG. Urinary excretion of D-glucarate, an indicator of drug metabolizing enzyme activity, in patients with impaired renal function. Eur J Clin Pharmacol 1980;18:255-61.
  6. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  7. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9.
  8. Walaszek Z, Hanausek-Walaszek M, Minton JP, Webb TE. Dietary glucarate as anti-promoter of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis. Carcinogenesis 1986;7:1463-6.
  9. Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake and excretion of D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21:178-90.