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Androstenetrione

What is androstenetrione (6-OXO)?

Androstenetrione (4-androstene 3,6,17-trione; androst -4-ene -3,6,17-trione), also known as 6-OXO, is a very strong aromatase inhibitor. Aromatase means the conversion of androgens such as testosterone into oestrogens. The inhibition of this enzyme leads to a low production of oestrogen. Because testosterone is a precursor to estrogen, the body signals to produce more testosterone to normalize estrogen levels. 6-OXO is one of the greatest discoveries in aromatase inhibitors to significantly increase testosterone levels.

What is post-cycle therapy?

The natural production of testosterone is controlled by the Hypothalamic-Pituitary-Testicular Axis (HPTA). When the body demands the need for testosterone, the HPTA releases GnRH (Gonadotropin-Releasing Hormone), which signals the release of LH (Luteinizing Hormone), which in turn signals the production of testosterone. When the missing testosterone requirement is met, this is signaled back to the HPTA. However, during a steroid/prohormone cure, the testosterone signals the HPTA that it no longer has a need. The HPTA then stops signaling the production of testosterone, which leads to the closure of the natural production of testosterone during a steroid cure. After a cure, natural testosterone production slowly normalizes. However, this process can take several months, depending on the type of dosage. During this time, anabolic hormones are reduced and the gains made during the cure may be lost. The aim is to normalize the natural production of testosterone as quickly as possible after the cure. Many athletes therefore use aromatase inhibitors such as HCG (human chorionic gonadotropin), SERMs (selective estrogen receptor modulators), Clomiphene (Clomid) and Tamoxifen (Nolvadex). In all cases, however, these are prescription drugs.

When is post-cycle therapy necessary?

PCT is necessary after every steroid/prohormone course, no matter what the substances are. Short courses (1-2 weeks) may be an exception, although PCT is recommended. The length of PCT depends on the longer the course. For a 4 week course it is advisable to PCT for 2-3 weeks and for a 12 week course up to 6 weeks. For longer cycles, the use of HCG is highly recommended.

What role does 6-OXO play in PCT?

*6-OXO* is the most effective over-the-counter PCT agent. By inhibiting estrogen production, the HPTA is signaled to increase and balance testosterone levels - that is, the 6-OXO inhibits one of the negative feedback signals that reduces signaling of testosterone production. This allows for the faster restoration of natural testosterone levels by additionally lowering estrogen levels.

Safety and side effects

6-OXO may not be safe and harmless. If it does increase testosterone levels in the body, the extra testosterone could cause serious side effects including liver problems, heart problems and cancer. The side effects of 6-OXO are those that can be expected from increased production of testosterone (and DHT). The most common complaint is acne (although this also shows that the product works). Increased sex drive is also to be expected. With long-term use, risks of BPH (prostate enlargement) and hair loss may be increased. The possibility of these side effects occurring can be reduced by the concomitant use of Finasteride (Propecia, Proscar) or Saw Palmetto.

Precautions and warnings

6-OXO may not be safe for everyone, but certain groups of people may have additional reasons to avoid 6-OXO:

Pregnancy and breastfeeding: not enough is known about the safety of 6-OXO during pregnancy and breastfeeding. For this reason, pregnant and breastfeeding women should avoid 6-OXO to be on the safe side.

Prostate cancer and other hormone-sensitive diseases: 6-OXO may increase testosterone levels. Men suffering from hormone-sensitive diseases such as prostate cancer should not use 6-OXO.

Liver diseases: 6-OXO could increase testosterone levels. An increase in testosterone levels is associated with liver problems. For this reason, you should not use 6-OXO if you have a liver condition.

If I have access to Clomid or Nolvadex, should I use it instead of 6-OXO?

There are many answers on this topic, but none conclusive. Many are more inclined to use a SERM for multiple reasons. One reason to favor one more over the other is a question that is not answered here, but both are good choices. My tip is for the individual to try both substances and see what works best for him.

At what dose should 6-OXO be used?

6-OXO should be started immediately at a high dose and tapered down weekly. The starting dose for the first week is usually 600mg, although some tend to use 800mg or more. Here are some examples:

After a 4-week course

  • Week 1: 600 mg
  • Week 2: 300 mg
  • Week 3: 100 mg

After a 6-week cure

  • Week 1: 600 mg

  • Week 2: 400 mg

  • Week 3: 300 mg

  • Week 4: 200 mg

    6-OXO only needs to be taken once a day.