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Opti MSM · 120 Kapseln

Opti MSM · 120 capsules

by GN Laboratories
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€19,90
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Methyl sulfonyl methane, better known as MSM or organic sulfur, is a natural supplement that has been shown in scientific studies not only to relieve joint pain and prevent joint problems (1). It also has an accelerating effect on regeneration and promotes the function of the immune system (2). Opti MSM from GN Laboratories delivers the active ingredient in its purest form - because in the end, only results count.

  • Supports joint health (1,2,3)
  • Could reduce joint pain and prevent joint problems (1)
  • Could promote regeneration after training (8)
  • Contributes to the function of the immune system (13)
  • Has an anti-inflammatory effect (4)
  • 1000 mg MSM per capsule
  • Highest quality - Made in Germany
Nährwerte und Inhaltsstoffe
Compositionper capsule% of the reference amount (NRV*)
Methyl sulfonyl methane1000 mg**


Zutaten: 86% methyl sulfonyl methane (brand name: OptiMSM®), capsule shell: hydroxyprophylmethyl celluslose

*Prozent der empfohlenen täglichen Verzehrmenge laut Verordnung (EU) Nr. 1196/2011

**Keine Nährstoffbezugswerte (NRV) vorhanden.

Verzehrempfehlung

Take 1-2 capsules daily with plenty of liquid.

Hinweise

Die angegebene empfohlene tägliche Verzehrsmenge darf nicht überschritten werden. Nahrungsergänzungsmittel sollten nicht als Ersatz für eine ausgewogene und abwechslungsreiche Ernährung verwendet werden. Das Produkt ist außerhalb der Reichweite von kleinen Kindern zu lagern.

Quellen
  1. Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013 Jan;31(1):16-25. doi: 10.1007/s00774-012-0378-9. Epub 2012 Aug 10. PMID: 23011466.
  2. Guerra C, Morris D, Sipin A, Kung S, Franklin M, Gray D, Tanzil M, Guilford F, Khasawneh FT, Venketaraman V. Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals. PLoS One. 2011;6(12):e28378. doi: 10.1371/journal.pone.0028378. Epub 2011 Dec 2. PMID: 22164280; PMCID: PMC3229597.
  3. Xu G, Zhou T, Gu Y, Wang Q, Shariff M, Gu P, Nguyen T, Shi R, Rao J. Evaluation of the Effect of Mega MSM on Improving Joint Function in Populations Experiencing Joint Degeneration. Int J Biomed Sci. 2015 Jun;11(2):54-60. PMID: 26199577; PMCID: PMC4502733.
  4. Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol Pharm Bull. 2009 Apr;32(4):651-6. doi: 10.1248/bpb.32.651. PMID: 19336900.
  5. Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50. doi: 10.1186/1472-6882-11-50. PMID: 21708034; PMCID: PMC3141601.
  6. Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial. Acta Med Indones. 2017 Apr;49(2):105-111. PMID: 28790224.
  7. Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A, Moretti B. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. Int J Immunopathol Pharmacol. 2016 Mar;29(1):140-6. doi: 10.1177/0394632015622215. Epub 2015 Dec 18. PMID: 26684635; PMCID: PMC5806735.
  8. Barmaki S, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi B. Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity. J Sports Med Phys Fitness. 2012 Apr;52(2):170-4. PMID: 22525653.
  9. Jackson MJ, Pye D, Palomero J. The production of reactive oxygen and nitrogen species by skeletal muscle. J Appl Physiol (1985). 2007 Apr;102(4):1664-70. doi: 10.1152/japplphysiol.01102.2006. Epub 2006 Nov 2. PMID: 17082364
  10. Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017 Jul 21;14:24. doi: 10.1186/s12970-017-0181-z. PMID: 28736511; PMCID: PMC5521097.
  11. Kalman, D., Feldman, S., Samson, A. and Krieger, D. (2013), A Randomized Double Blind Placebo Controlled Evaluation of MSM for Exercise Induced Discomfort/Pain… The FASEB Journal, 27: 1076.7-1076.7. https://doi.org/10.1096/fasebj.27.1_supplement.1076.7
  12. Guerra C, Morris D, Sipin A, Kung S, Franklin M, Gray D, Tanzil M, Guilford F, Khasawneh FT, Venketaraman V. Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals. PLoS One. 2011;6(12):e28378. doi: 10.1371/journal.pone.0028378. Epub 2011 Dec 2. PMID: 22164280; PMCID: PMC3229597.
  13. Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007 Nov 6;4:24. doi: 10.1186/1743-7075-4-24. PMID: 17986345; PMCID: PMC2198910.
  14. 14. Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, et al. The Effect of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. doi:10.1155/2016/7498359.
  15. Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. doi: 10.1101/cshperspect.a001651. Epub 2009 Oct 7. PMID: 20457564; PMCID: PMC2882124.
  16. Lin L, Peng Y, Chen F, et al. Inflammation and cardiovascular disease mechanisms. Linking microbes, inflammation and gut dysfunction. J Intern Med. 2019 Apr;285(4):438-448. doi: 10.1111/joim.12866.
  17. Pérez-Cano FJ, Franch A, Castellote C. Castell M. Immunomodulatory action of compounds isolated from unsaponifiable fraction of extra virgin olive oil via NF-κB pathway. Journal of Functional Foods. 2016 Oct;26:650-663. doi: 10.1016/j.jff.2016.08.014.
  18. S. Hexsel, M. Zague, V.S. Schunck, G. Siega, A. Camozzato Fo, A. Oesser. The effect of methylsulfonylmethane on hair and nail health. Clinical, Cosmetic and Investigational Dermatology. 2015; 8: 389–397. doi: 10.2147/CCID.S84929.
  19. Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC. Discovering the link between nutrition and skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):298-307. doi: 10.4161/derm.22876. PMID: 23467449; PMCID: PMC3583891.
  20. Berardesca E, Cameli N, Cavallotti C, Levy JL, Piérard GE, de Paoli Ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008 Mar;7(1):8-14. doi: 10.1111/j.1473-2165.2008.00355.x. PMID: 18254805.

Inhalt: 120 capsules Artikelnr.: 7671

What is MSM and how does it work?

MSM is short for methylsulfonylmethane - a readily available biological source of organic sulfur found in animals, plants and the human body. MSM has long been used in sports and medicine to relieve joint pain and prevent joint problems (1,3). Hard training sessions with heavy weights and intensive endurance training can put a lot of strain on joints. According to researchers, this can lead to significant wear and tear of the joints and inflammatory diseases of the joints over the course of a training career. Studies have found that MSM was able to protect the joint cartilage of test subjects from such degradation (1,3). The readily bioavailable sulphur contained in MSM is an important component of human cartilage tissue, which means that it can prevent joint problems (1,3). However, MSM also showed an effect in studies when joint problems and joint pain were already present in test subjects. In addition to its joint-protective properties, MSM also has pronounced anti-inflammatory effects, according to scientists. For the test subjects in the studies, this meant that not only was the regeneration of damaged joints promoted, but joint pain could also be alleviated (4). However, the effect of MSM is not limited to sports-related joint problems. Studies have also shown MSM to be helpful for age-related joint problems such as osteoarthritis (5, 6, 7).

However, the benefits of MSM that have been proven in studies do not end there. Another point in favor of MSM is that it was shown in a study to promote regeneration after intensive training sessions and hard physical exertion in test subjects (8). As everyone knows, hard training sessions can lead to muscle damage and muscle soreness and thus inevitably to increased levels of free radicals. These can damage muscle cells as well as many other cells in the body (9). Scientific studies have shown that MSM was able to significantly reduce exercise-induced muscle damage, muscle soreness and joint pain in test subjects after training (10, 11). In addition, MSM was also able to increase the levels of the body's most powerful antioxidant, glutathione, which can quickly and effectively reduce the increased levels of free radicals caused by exercise (12). Another effect that studies have shown for MSM is a supportive effect on the immune system in general. Really intensive training sessions can reduce the function of the immune system for several hours immediately after training, which can increase susceptibility to infectious diseases. Sulphur compounds such as MSM play an important role in the health of the immune system (13). Scientific studies have shown that taking MSM before strenuous training sessions can reduce the release of pro-inflammatory cytokines in the test group and thus prevent immune cells from being overloaded (14).

What other benefits can a regular intake of MSM bring?

Due to its anti-inflammatory effect, which researchers attribute to the inhibition of the protein complex NF-kB, among other things, MSM was able to counteract chronic inflammation in the body of the test subjects in one study (15). These generally contribute to the development and exacerbation of a variety of diseases including cardiovascular disease, stomach ulcers and diabetes (16, 17). The skin is another area that depends on an optimal supply of sulphur in the body. The keratin contained in our skin is a protein that serves as the main structural component of our hair, skin and nails. Keratin contains a comparatively large proportion of the amino acid cysteine. This has a high sulphur content, which is where the characteristic smell of sulphur comes from when hair burns. In a study, MSM was found to have a positive effect on the skin health of test subjects, as it can be used as a source of sulphur for keratin in the human body (18). MSM also helps to reduce inflammatory processes that can otherwise damage the skin and cause signs of premature ageing such as wrinkles (19). It has even been shown in studies to alleviate the symptoms of more serious skin conditions such as rosacea in test subjects, significantly improving redness, itching, inflammation, hydration and skin color (20).

Considering the numerous studies that have been conducted on methyl sulfonyl methane, it is not surprising that it has long been used in sports and medicine to relieve joint pain and prevent joint problems. MSM has been shown to have a positive effect on the human body in various areas and is therefore also very popular as a supplement. As always, GN provides you with the active ingredient in its purest form and in the usual top quality, so it can unfold its full effect where it is needed. **Opti MSM from GN Laboratories - because in the end only results count.

Customer Reviews

Based on 3 reviews
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R
Roman Wochner
MSM mal als einzelnes Supplement ist echt super

Supper Supplement für die Gelenke schön dass es das hier einzeln zu kaufen gibt

K
Knut Wister
OptiMsM

Markenrohstoff und das merkt man.

M
Mareike J.
MSM wirkt

Hab das Supplement das erste Mal in einem Kombisupplement für die gelenke genommen, jetzt bin ich zum ersten mal mal auf den Wirkstoff als einzele Komponente übergegangen. Bin von den Eigenschaften von MSM echt begeistert, man merkt deutlich dass es gut tut.