Skip to content

Berberine · 120 capsules

Original price €24,90 - Original price €24,90
Original price €24,90
€24,90
€24,90 - €24,90
Current price €24,90
Benachrichtige mich, wenn vorrätig
  • PayPal
  • Amazon
  • Visa
  • Mastercard
  • American Express
  • SOFORT
  • Klarna
Berberine has a reputation for having numerous positive effects on the body. Many of these effects have been investigated in scientific studies and have been proven in various test groups.
  • Numerous effects
  • Scientifically proven
  • High dosage
  • 150 mg berberine per capsule
  • Easy to dose capsule form
  • Proven quality - Made in Germany
Nährwerte und Inhaltsstoffe
Compositionper capsule
Berberine hydrochloride
150 mg


Zutaten: Chinese golden threadroot extract (95% berberine HCL), coating agent: hydroxypropyl methylcellulose (vegetable capsule shell), bulking agent: microcrystalline cellulose.

*Prozent der empfohlenen täglichen Verzehrmenge laut Verordnung (EU) Nr. 1196/2011

**Keine Nährstoffbezugswerte (NRV) vorhanden.

Verzehrempfehlung

Take 1 capsule daily unchewed with plenty of water.

Hinweise

Die angegebene empfohlene tägliche Verzehrsmenge darf nicht überschritten werden. Nahrungsergänzungsmittel sollten nicht als Ersatz für eine ausgewogene und abwechslungsreiche Ernährung verwendet werden. Das Produkt ist außerhalb der Reichweite von kleinen Kindern zu lagern.

Quellen
  1. Kulkarni, S. K., & Dhir, A. (2010). Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytotherapy Research, 24(3), 317-324.
  2. Yin, J., Xing, H., Ye, J., & Efficacy, S. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57(5), 712-717.
  3. Kong, W. J., Wei, J., Abidi, P., Lin, M. H., Inaba, S., Li, C., ... & Li, Y. C. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature medicine, 10(12), 1344-1351.
  4. Zhang, Y., Li, X. J., Yan, F. F., & Sun, H. R. (2010). The effects of berberine on hepatic LDLR mRNA and protein expression in rats with non-alcoholic fatty liver disease. Pharmaceutical biology, 48(3), 315-321.
  5. Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., ... & Ning, G. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of Clinical Endocrinology & Metabolism, 93(7), 2559-2565.
  6. Dong, H., Wang, N., Zhao, L., & Lu, F. (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine, 2012.
  7. Yin, J., Ye, J., Jia, W., & Efficacy, S. (2008). Effects and mechanisms of berberine in diabetes treatment. Acta Pharmacologica Sinica, 29(10), 1149-1163.
  8. Wang, Y., & Campbell, T. (2017). Berberine enhances insulin receptor signaling and modifies gene expression of glucose metabolism, inflammation, and mitochondrial biogenesis in culturing human skeletal muscle cells. Evidence-Based Complementary and Alternative Medicine, 2017.
  9. Kong WJ, Wei J, Zuo ZY, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004;10(12):1344-1351. doi:10.1038/nm1135
  10. Derosa, G., Maffioli, P., & Cicero, A. F. (2015). Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials. Expert Opinion on Biological Therapy, 15(9), 1297-1306.
  11. Wu, X., Li, Q., Xin, H., Yu, A., Zhong, M., & Guo, X. (2017). Anti-inflammatory and antibacterial activity of berberine in an infected pressure ulcer model. Molecular Medicine Reports, 16(2), 1297-1303.
  12. Sun, X., & Lv, F. (2015). Berberine: pathway validation and drug discovery. Expert Opinion on Drug Discovery, 10(10), 1033-1044.
  13. Dong, H., Wang, N., Zhao, L., Lu, F. E., & Xu, L. J. (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-based complementary and alternative medicine, 2012, 591654. https://doi.org/10.1155/2012/591654
  14. Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012). AMP-activated protein kinase: a target for drugs both ancient and modern. Chemistry & biology, 19(10), 1222-1236. https://doi.org/10.1016/j.chembiol.2012.08.019
  15. Wu, L., Xia, M., Duan, Y., Zhang, L., Jiang, H., Hu, X., Yan, H., Zhang, Y., Gu, J., & Xiang, S. (2014). Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. Cell death & disease, 5(2), e1306. https://doi.org/10.1038/cddis.2014.274
  16. Chang, W., Zhang, M., Li, J., Meng, Z., Wei, S., Du, H., & Zhang, Y. (2013). Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase. Metabolism, 62(8), 1159-1167. https://doi.org
  17. Yin, J., Xing, H., Ye, J., & Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy research : PTR, 2019. https://doi.org/10.1002/ptr.6549
  18. Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81. https://doi.org/10.1016/j.jep.2014.09.049
  19. Huang, X., Liu, G., Guo, J., Su, Z. (2015). The PI3K/Akt pathway mediates the anti-apoptotic effect of berberine in the rat remnant kidney model. International Journal of Molecular Sciences, 16(2), 3092-3105. doi: 10.3390/ijms16023092
  20. Wang Y, Huang Y, Lam KS. Berberine and its derivatives: a patent review (2009-2012). Expert Opin Ther Pat. 2012;22(8):969-984.
  21. Gerard J, Soriano García J, Romo-Mancillas A, González-Cortazar M, Guzmán-Grenfell AM, Sánchez-Sevilla L. Effect of Berberine on Inflammatory and Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Antioxidants (Basel). 2021;10(2):282. doi: 10.3390/antiox10020282. PMID: 33673056; PMCID: PMC7914246.

Inhalt: 120 capsules Artikelnr.: 6792

What is berberine?

Berberine is an alkaloid that occurs naturally in the roots, bark, leaves and root stem of a number of plants. These plants include barberry, which gave the alkaloid its name. Berberine has been used for centuries in traditional Chinese medicine and traditional Ayurvedic medicine. It is a popular remedy for treating various diseases and ailments. Numerous studies have shown that berberine has a whole range of potentially health-promoting biological effects in the body (1,2,3). Most human studies have investigated the effect of berberine on blood sugar control (2), blood lipids (3) and liver function (4). In other words, the main effects that have been investigated may not only be beneficial for bodybuilders and other athletes, but could also have a positive effect on health and well-being in general.

What are the health benefits of berberine?

Probably one of the most interesting health benefits of berberine is its effect on the regulation of blood sugar levels. Numerous studies have shown that berberine can significantly reduce not only the acute blood glucose levels of subjects after a meal, but also HbA1c, which is a marker of average blood glucose levels over the past few months (5,6). Researchers even came to the conclusion in a study that berberine could be just as effective as the well-known drug metformin in terms of blood sugar levels (7). According to the researchers, this effect appears to be based on the AMPK activation already described. This activation ensures an increased transport of glucose into the cells of the body. However, it also includes an acceleration of the repair of the insulin-producing beta cells of the pancreas, as well as an increase in the effect of insulin via an increase in the expression of insulin receptors on the surface of body cells and a slower breakdown of carbohydrates in the liver (8). In addition, according to various studies, berberine has a whole range of properties that can support and improve the health of the cardiovascular system. These include the ability to reduce levels of "bad" LDL cholesterol and blood lipid levels, as well as increasing levels of "good" HDL cholesterol (9). Other effects that have been shown to have a positive impact on cardiovascular health in test subjects include widening of the coronary arteries and alleviation of cardiac arrhythmias (9,10). In scientific studies, berberine has also shown the ability to fight dangerous pathogens such as bacteria, viruses, fungi and parasites (11). It even had a moderate antibiotic effect, which enabled it to support and improve the function of the immune system in the test subjects (11,12). These effects have been known for centuries and berberine was probably already used as an intestinal antiseptic in the ancient Orient due to these properties.

What are the benefits of berberine for athletes and bodybuilders?

One of the most interesting properties of berberine for strength athletes is probably its ability to activate an enzyme called AMPK in the body. This effect was demonstrated in a study on various test subjects (13). AMPK is also referred to by scientists as the "master switch of metabolism", as it plays a primary role in the regulation of metabolism (14). AMPK is an enzyme that is also activated by physical exercise. Among other things, it increases the transport of fatty acids and glucose into the muscle cells, where it stimulates the burning of these energy sources (15). At the same time, it actively inhibited the build-up of body fat in test subjects (16), which is also an interesting effect for dieters. For athletes and bodybuilders, the results of the studies show increased training energy and greater muscle endurance during intensive and strenuous training sessions. For figure-conscious people who want to lose fat or maintain a low body fat percentage, the stimulation of the metabolism and increased fat burning could help them lose weight faster and maintain their weight more easily (17). The fat loss-promoting effects of berberine have also been demonstrated in a number of clinical studies (2,18,19). Of course, the improved regulation of blood sugar levels by berberine, which we have already discussed, could potentially further support a diet by preventing blood sugar fluctuations and food cravings. In addition, berberine has pronounced antioxidant properties (20,21) and can therefore protect the body's (muscle) cells and DNA from damage and destruction by free radicals. Together with the anti-inflammatory properties of berberine found in test subjects (2,21), this can promote and accelerate regeneration after training.

Whether you are an athlete or not, if you look at the various effects that berberine has shown in numerous studies, you quickly realize why it has been used for so many years. It has been shown repeatedly in scientific studies to be an integral part of traditional medicine and is also used to influence various aspects of human health. GN - Laboratories supplies berberine of the highest quality so that you can fully benefit from it. Berberine from GN Laboratories - because in the end only results count.

Customer Reviews

Based on 11 reviews
91%
(10)
0%
(0)
9%
(1)
0%
(0)
0%
(0)
S
S.K.
Zu niedrig dosiert!!

Bei einer empfohlenen Dosierung von 3 x 500mg am Tag ist der Kapselinhalt zu niedrig dosiert. Gibt gute Alternativen, bitte gogglen!

C
Chao L.
Unfassbarer Wirkstoff

Leider eines der Supplements die deutlich zu wenig Aufmerksamkeit bekommen.

S
Sina B.
Top Preis-Leistung

Klasse Produkt, habe nichts zu beanstanden. Klare Empfehlung

V
Vasili B.
Gut für die Regeneration

Bin nach dem Training deutlich schneller wieder fit und Einsatzbereit echt ein super Stoff

B
Brian W
Voll zufrieden

Top Produkt, Klasse Preis Leistung, bin voll und ganz zufrieden.