CLA needs D6D to promote fat loss

Conjugated Linoleic Acid (CLA) is a popular supplement among bodybuilders because it breaks down fat in the abdominal area and reduces inflammation associated with insulin resistance, diabetes and poor sexual performance. CLA is a fatty acid found in beef and the fat in dairy products and is also available in higher concentrations in supplement form.

Most studies conducted on animals but only 50 percent of human studies showed that CLA reduces body fat. We can conclude from this that there are people who respond to this supplement and others who do not. A study conducted at the University of Nebraska under the direction of Kimberly Hargrave-Barns showed that CLA-induced fat loss depends on an enzyme called alpha-6-desaturase (D6D). Genetic and environmental factors influence the activity of D6D and therefore the capacity of CLA to promote fat loss. These factors include aging, smoking, insulin resistance, inadequate intakes of vitamin B6, magnesium and zinc, poor metabolic health and high intakes of saturated and trans fats. People who have a genetic predisposition to obesity, such as Pima Indians, have low D6D levels.

This study sends an important message: a drug or supplement that works for one person may not necessarily work for another.
(Obesity, in press, published online July 24, 2008)