Meltdown

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Powerful Fat Loss Agent With Mind & Craving Control Matrix! Size: 120 Bioliquid Capsules

Product No.: 1689

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Fatburner of the year 2009



Powerful Fat Loss Agent With Mind & Craving Control Matrix!

What’s the supplement that burns fat faster than an ice cube melts in the Sahara? Meltdown® mi amigo! In a study presented at the June 2008 International Society of Sports Nutrition Conference in the beautiful Red Rock Hotel, researchers discovered that this fat-blasting supplement jacked up metabolic rate so much so that it left scientists scratching their heads as to how it compared to other popular thermogenics. That’s a finding of tsunamic proportions.1

What does this mean? Think about it Sherlock. If you take Meltdown before training, your metabolic rate will go through the roof faster than Anderson Silva can put you in an arm bar! You’ll lose fat faster and you’ll get that lean physique you’ve always wanted.

The R & D group at VPX has more ground-breaking science coming down the pike this year. So buckle your chinstraps and get ready for the ride of your thermogenic life! Hasta la vista!

References

1. Astrup A, Toubro S, Cannon S, Hein P, Madsen J. Thermogenic synergism between ephedrine and caffeine in healthy volunteers: a double-blind, placebo-controlled study. Metabolism. Mar 1991;40(3):323-329.

Synephrine and Methyl Synephrine: Lipolytic Potential

What is Synephrine?
Citrus aurantium (also known as Bitter Orange, Sour Orange, and Seville Orange) is a relatively small citrus tree about 5 meters tall with scented white flowers (Fugh-Berman and Myers, 2004). As the name implies, the fruit is quite bitter and for this reason, it is not commonly used for culinary purposes. However, the dried, entire unripe fruit of Citrus aurantium has been used as an Asian herbal medicine primarily to treat digestive problems. More specific to this article, the greatest interest recently has been in the active alkaloids of the Citrus aurantium, synephrine (oxedrine) and octopamine (Nelson et al., 2007), which are structurally similar to epinephrine and norepinephrine, respectively. Both synephrine and octopamine are considered trace endogenous bioamines, with circulating levels noted in the plasma of healthy men and women (D'Andrea et al., 2003). Synephrine has alpha-adrenergic effects and also activates beta-3 receptors (but not beta-1 or beta-2 receptors). These effects highlight the potential mechanism of action of this agent related to thermogenesis and lipolysis.

Compounds contained within the Citrus aurantium, such as synephrine, have adrenergic effects that may result in lipolysis and appetite suppression (Fugh-Berman and Myers, 2004).

Synephrine, Thermogenesis and Fat/Weight Loss
As stated above, synephrine is a chief ingredient in many popular fat/weight loss formulas on the market today. Claims for this ingredient include "increased fat burning", "increased energy", "increased metabolism and thermogenesis", and "increased fat/weight loss". As with many nutritional supplements, the claims are largely unsupported by scientific investigation, in particular at the recommended dosage. Some review articles related to the use of Citrus aurantium (or synephrine) as a weight loss aid indicate that little to no evidence exists for such an effect in human subjects (Bent et al., 2004; Fugh-Berman and Myers, 2004; Preuss et al., 2002), while one recent review suggests that "some evidence is promising" (Haaz et al., 2006).

The use of Citrus aurantium or synephrine as a weight loss agent may be based on a study reporting that both synephrine and octopamine will bind to beta 3-receptors, thereby promoting lipolysis (Carpene et al., 1999). Interestingly, octopamine was found to be superior to synephrine in stimulating the beta 3-receptors, as significance was only noted for the synephrine when given at very high dosages (Carpene et al., 1999). This may be the reason that octopamine has been shown to yield a decrease in body weight when administered to rodents (Bour et al., 2003). However, it should be noted that while beta-3 receptor agonists do have lipolytic effects in fat cells of animals, they appear far less active in human fat cells. That is, Larsen et al. (2002) reported no difference in 24 hour energy expenditure, respiratory quotient, or body composition measures in obese men following 28 days of treatment with a selective beta-3 receptor agonist, when compared to placebo.

There have only been a handful of controlled studies focused on either Citrus aurantium or synephrine, with the inclusion of fat/weight loss as an outcome variable (Armstrong et al., 2001; Colker et al., 1999; Kalman et al., 2000). In each of these studies, the amount of weight lost was slightly greater for those using the supplement compared to those using the placebo. However, in all of these studies the supplement consisted of a combination of ingredients (e.g., Citrus aurantium, caffeine, Ginko biloba, St. John's Wort, etc.). Therefore, it is impossible to determine the independent contribution of Citrus aurantium or synephrine on weight loss in these studies. Clearly, more research involving human subjects is needed to shed light on the potential role of synephrine as a fat/weight loss aid.

Methyl Synephrine, Thermogenesis and Fat/Weight Loss
Considering the above reports related to the minimal efficacy of ordinary synephrine to yield significant effects on thermogenesis and body fat/weight loss, a novel form of synephrine has recently been developed called methyl synephrine. Methylation is a common term used in chemistry and biochemistry to denote the attachment or substitution of a methyl group onto various molecules. In doing so, the scientists who have engineered this compound suggest that the therrmogenic effects of synephrine are greatly amplified, yielding a profound effect on fat/weight loss. While anecdotal "in the gym" accounts of subjects using methyl synephrine have been noted as highly favorable, controlled testing of this novel methylated version is necessary before firm conclusions can be drawn related to its ability to function as a potent lipolytic agent.

Hemodynamic Effects of Synephrine: Safety Issues
One concern many individuals have with synephrine is the possible stimulatory effect on the cardiovascular system, in particular heart rate and blood pressure. The hemodynamic changes following a single dose intake of synephrine containing dietary supplements has been investigated, with minimal increase noted in either heart rate or blood pressure (Bui et al., 2006; Colker et al. 1999; Haller et al., 2005; Penzak et al., 2001). For example, Penzak and colleagues (2001) had subjects consume 8 oz of Seville Orange Juice and water, on two different occasions, and noted minimal difference in heart rate or blood pressure between the two trials. Other studies have noted "statistically significant" differences in heart rate or blood pressure when subjects ingest dietary supplements containing Citrus aurantium (Bui et al., 2006) or synephrine (Haller et al., 2005). However, the increase has been noted as small (e.g., 7-10mmHg in blood pressure and 4-11 beats per minute in heart rate). Therefore, it does not appear that otherwise healthy individuals would experience any adverse outcome as a result of normal, suggested dosing.

Practical Applications of Synephrine
In conclusion, the evidence for the use of ordinary synephrine as a fat/weight loss aid is scant at best. While a few studies have noted small improvements in weight loss when using dietary supplements containing synephrine, the absolute difference between synephrine and placebo groups has been minimal. The novel form of this alkaloid, methyl synephrine, has been touted as a much more potent lipolytic agent. Anecdotal reports indicate this as such; however, clinical trials are needed to confirm these observations. Finally, data indicate only a mild increase in both heart rate and blood pressure with use of synephrine containing dietary supplements. Hence, this alkaloid may be considered safe for supplementation purposes when used as recommended.

References

1. Armstrong WJ, Johnson P, Duhme S. The effect of commercial thermogenic weight loss supplement in body composition and energy expenditure in obese adults. J Exerc Physiol. 2001 4: 28-35, 2001.
2. Bent S, Padula A, Neuhaus J. Safety and efficacy of citrus aurantium for weight loss. Am J Cardiol. 2004 Nov 15;94(10):1359-61.
3. Bour S, Visentin V, Prévot D, Carpéné C. Moderate weight-lowering effect of octopamine treatment in obese Zucker rats. J Physiol Biochem. 2003 Sep;59(3):175-82.
4. Bui LT, Nguyen DT, Ambrose PJ. Blood pressure and heart rate effects following a single dose of bitter orange. Ann Pharmacother. 2006 Jan;40(1):53-7. Epub 2005 Nov 29.
5. Carpéné C, Galitzky J, Fontana E, Atgié C, Lafontan M, Berlan M. Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):310-21.
6. Colker CM, Kalman DS, Torina GC, Perlis T, Street C. Effects of Citrus aurantium extract, caffeine, and St. John's Wort on body fat loss, lipid levels, and mood states in overweight, healthy adults. Curr Ther Res. 1999; 60:145-153.
7. D'Andrea G, Terrazzino S, Fortin D, Farruggio A, Rinaldi L, Leon A. HPLC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine receptors in circulating leukocytes. Neurosci Lett. 2003 Jul 31;346(1-2):89-92.
8. Fugh-Berman A, Myers A. Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp Biol Med (Maywood). 2004 Sep;229(8):698-704.
9. Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev. 2006 Feb;7(1):79-88.
10. Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med. 2005 Sep;118(9):998-1003.
11. Hofstetter R, Kreuder J, von Bernuth G.[The effect of oxedrine on the left ventricle and peripheral vascular resistance] Arzneimittelforschung. 1985;35(12):1844-6.
12. Kalman DS, Colker CM, Shi Q, Swain MA. Effects of a weight loss aid in healthy overweight adults: double-blind, placebo-controlled clinical trial. Current Therapeutic Res 61: 199-2005, 2000.
13. Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, Astrup A. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr. 2002 Oct;76(4):780-8.
14. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem. 2007 Nov 28;55(24):9769-75.
15. Penzak SR, Jann MW, Cold JA, Hon YY, Desai HD, Gurley BJ. Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. J Clin Pharmacol. 2001 Oct;41(10):1059-63.
16. Preuss HG, DiFerdinando D, Bagchi M, Bagchi D. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. J Med. 2002;33(1-4):247-64.

ß-Phenylethylamine as a Dietary Supplement

What is ß-phenylethylamine?
Beta-phenylethylamine (PEA) is a trace amine found within mammalian brain tissue, in particular within the limbic region (Patterson et al., 1990). Beta-phenylethylamine can be synthesized in the body by the enzymatic decarboxylation of the amino acid phenylalanine. Beta-phenylethylamine and its derivatives are also found in high concentrations within plants (Smith, 1977). Thus, individuals may consume PEA regularly as a component of the diet, as it is found in both chocolate and the oil of bitter almonds. It can also be exogenously taken as a pharmaceutical agent or as a dietary supplement. Regardless of delivery, the effects of PEA (as discussed below) appear to be short lived, in that this substance is rapidly metabolized by type B monoamine oxidase (Bakhle and Youdim, 1976; Cooper and Dourish, 1984).

What are the physiological effects of ß-phenylethylamine?
Since the discovery of PEA in the 1960s, it has been investigated extensively within neurochemical, neuropharmacological, and neurophysiological contexts. Beta-phenylethylamine has been reported to act on presynaptic dopaminergic nerve terminals to stimulate the release of dopamine (Bailey et al., 1987; Nakamura et al., 1998; Raiteri et al., 1977). Because dopamine is commonly associated with the pleasure system of the brain and considered a "feel good" hormone/ neurotransmitter, PEA has been routinely associated with the feeling of euphoria. Beta-phenylethylamine is also noted to exert similar effects as those of exogenous amphetamines, and is therefore referred to as an "endogenous amphetamine" (Popplewell et al., 1986). The specific outcomes related to these effects are discussed below.

Mood
The association between PEA and improved mood is likely the most well investigated aspect of research associated with this substance. The stimulating effects of PEA are likely related to its role in activating the release of dopamine.

In terms of consumption of PEA as a dietary supplement or nutrient found in food, the increase in dopamine may result in an increase in feelings of euphoria. It may also serve to depress food cravings and appetite (as discussed below). In particular, it has been suggested that the psychoactive effects and feelings of euphoria associated with chocolate consumption are due to PEA. However, it should be understood that PEA likely needs to be consumed regularly and/ or in large quantities in order to see long lasting effects, as it is rapidly degraded by type B monoamine oxidase (Bakhle and Youdim, 1976; Cooper and Dourish, 1984), as mentioned above. Use of type B monoamine oxidase inhibitors can dramatically increase the PEA levels, which has been suggested to potentiate dopamine and catecholamine function in the central nervous system (Yu, 1994).

Activity
Behavioral studies have demonstrated that PEA induces a significant increase in locomotor activity (Cooper and Dourish, 1984; Dourish et al., 1983; Popplewell et al., 1986). This may be due to the amphetamine-like effect of PEA. Such findings may have implications related to increased physical activity, possibly mediating enhanced health and weight loss. That is, if supplemental PEA leads to increased physical activity, the increase in caloric expenditure may be associated with favorable changes in body weight.

Appetite
One early study has demonstrated that acute and chronic administration of PEA (once weekly for four weeks) causes a significant reduction in 24 hour food intake, and causes a dose dependent reduction in body weight gain in rats (Dourish and Boulton, 1981). Interestingly, no tolerance to PEA administration was noted (i.e., the effects did not decrease over time). Although these effects have yet to be confirmed in human subjects, it is possible that similar effects may be observed. If so, administration of PEA may prove as an adjunct treatment during periods of calorie restrictive dieting.

Energy Metabolism
Beta-phenylethylamine appears to regulate catecholamine (epinephrine and norepinephrine; AKA, adrenaline and noradrenaline) concentrations, as its presence has been shown to stimulate blood catecholamine levels and inhibit their reuptake (Patterson et al., 1990). Based on these findings, it is possible that PEA may serve a useful role in lipolysis; that is, the breakdown of stored body fat. This is because the catecholamine hormones act on hormone sensitive lipase, the rate limiting enzyme for fatty acid mobilization from storage sites. They do this through a complex interplay between hormones, receptors, and "second messengers". Both epinephrine and norepinephrine interact with beta-adrenergic receptors located on adipose tissue to ultimately lead to fatty acid mobilization into circulation to be used as a fuel source (i.e., to be "burned"). Therefore, it is possible that an increase in the concentration of PEA can exert a stimulating effect on energy metabolism, as well as on the other aforementioned components affected by catecholamine stimulation (e.g., enhanced mood, excitement, etc.). For this reason, PEA may have a use as a "fat burning" agent. Well controlled studies are needed to investigate this hypothesis.

n-methyl-ß-phenylethylamine and R-ß-methyl-phenylethylamine
Novel forms of PEA such as n-methyl-ß-phenylethylamine and R-?-methyl- phenylethylamine have been used recently in dietary supplement preparations. These forms have been suggested to be more resistance to degradation via type B monoamine oxidase; hence, impart a longer lasting and greater effect of PEA. Moreover, they have been suggested to have a greater ability to cross the blood brain barrier, possibly leading to enhanced feelings of euphoria. Although some early study pertaining to these forms has been conducted (Camp et al., 1970), as with the other areas of investigation, additional study is needed to confirm the above theories.

Summary
Beta-phenylethylamine is a well studied substance that has documented effects on both dopamine release and maintenance of catecholamines. This may translate into enhanced feelings of euphoria, mood, and energy. Moreover, the increase in catecholamine levels may stimulate an increase in lipolysis (fat breakdown), which may prove helpful during periods of calorie restrictive dieting. Novel forms of PEA are currently being used in dietary supplement preparations. While these forms appear interesting and may prove more effective than traditional PEA, further research is necessary to confirm the proposed benefits.

References

1. Bailey BA, Phillips SR, Boulton AA, In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987, 12: 173-178.
2. Bakhle YS, and Youdim MB. Metabolism of phenylethylamine in rat isolated perfused lung: evidence for monoamine oxidase 'type B' in lung. Br J Pharmacol. 1976, 56(1): 125-127.
3. Camp BJ. Action of N-methyltyramine and N-methyl beta-phenylethylamine on certain biological systems. Am J Vet Res. 1970, 31(4): 755-762.
4. Cooper SJ, Dourish CT. Hypodipsia, stereotypy and hyperactivity induced by beta-phenylethylamine in the water-deprived rat. Pharmacol Biochem Behav. 1984, 20(1): 1-7.
5. Dourish CT, Greenshaw AJ, Boulton AA. Deutrium substitution enhances the effects of b-phenylethylamine on spontaneous motor activity in the rat. Pharmacol. Biochem. Behav. 1983, 19: 471-475.
6. Dourish CT, Boulton AA. The effects of acute and chronic administration of beta-phenylethylamine on food intake and body weight in rats. Prog Neuropsychopharmacol. 1981, 5(4): 411-414.
7. Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997, 17(2): 206-210.
8. Nakamura M, Ishii A, Nakahara D. Characterization of b-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur. J. Pharmacol. 1998, 349: 163-169.
9. O'Reilly R, Davis BA, Durden DA, Thorpe L, Machnee H, Boulton AA. Plasma phenylethylamine in schizophrenic patients. Biol Psychiatry. 1991, 30(2): 145-150.
10. Paterson IA, Juorio AV, Boulton AA. 2-Phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system? J. Neurochem. 1990, 55: 1827-1837.
11. Popplewell DA, Coffey PJ, Montgomery AM, Burton MJ. A behavioural and pharmacological examination of phenylethylamine-induced anorexia and hyperactivity--comparisons with amphetamine. Pharmacol Biochem Behav. 1986, 25(4): 711-716.
12. Raiteri M, Del Carmine R, Bertollini A, Levi G. Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine, and 5-hydroxytryptamine. Eur J Pharmacol 1977, 41: 133-143.
13. Sabelli HC, Javaid JI. Phenylethylamine modulation of affect: therapeutic and diagnostic implications. J Neuropsychiatry Clin Neurosci. 1995, 7(1): 6-14.
14. Smith TA. Phenylethylamine and related compounds in plants. Phytochemistry 1977, 16: 9-18.
15. Yu PH. Pharmacological and clinical implications of MAO-B inhibitors. Gen Pharmacol. 1994, 25(8): 1527-1539.

Meltdown® by VPX is one of the most profound scientific fat loss innovation of the decade. Meltdown has a star studded ingredient profile of newly invented exclusive fat loss compounds designed to burn fat faster and longer by kicking up a thermogenic storm! And that’s just the tip of a very large iceberg of fat burning science. Meltdown will radically increase energy levels, take mental acuity and alertness into the stratosphere and induce an intense mood-altering euphoric effect that is going to re-write fat loss biochemistry.

The Yohimbine Synergistic Fat Loss Trifecta
Yohimbine is an alpha-2-antagonist which simply means it exerts its fat loss effect by blocking the alpha-2 receptors. Blocking action of the alpha-2 receptors is critical for fat loss because it increases blood flow in adipose tissue and as a result ramps up internal fat metabolism causing previously stored body fat to be released into the blood stream and burned as energy. This process is known as Lipolysis. Yohimbine also works by increasing Norepinephrine (NE) - one of the body’s principal lipolytic (fat burning) hormones. The challenge is that when NE is released it stimulates both the alpha and beta receptors. While stimulating the beta receptors causes the desired effect of fat liberation, NE simultaneously also stimulates the alpha-2 receptors which can have the undesired effect of interfering with the process of body fat being burned as energy. Yohimbine is a really cool substance because it exerts a kind of self-protective mechanism by blocking the alpha-2 receptors and guarding one of the body’s key fat burning hormones called Norepinephrine. Simply stated, it is almost like Yohimbine has a mind of its own that says I’m going to increase NE to destroy body fat and nothing is going to get in my way.

Because of the sheer fat burning potency of Yohimbine, we analyzed this chemical very closely and now introduce two new forms (along with Yohimbine HCl) of Yohimbine in Meltdown. Consequently, Meltdown contains three specialized forms of the potent fat loss agent, Yohimbine. Along with pure Yohimbine HCl, Meltdown now contains 11-Hydroxy Yohimbine which has unusually long half-life and, therefore, exerts a prolonged research-proven fat burning effect for up to eight hours while increasing norepinephrine levels by up to 56%! This is important because Norepinephrine (NE) is one of the body's principal lipolytic (fat burning) hormones. Further, Meltdown also contains the rare alpha-Yohimbine compound. The scientific marvel is that Yohimbine HCl, 11-Hydroxy Yohimbine and alpha-Yohimbine work synergistically to increases lipolysis. These compounds work particularly well in the stubborn areas of the butt, thighs and abdomen because of the Yohimbine receptor cites concentrated in those areas.

Meltdown® Research And Development Project
Interestingly, most of these compound innovations contained in Meltdown didn't even exist and had to be chemically engineered in the lab. For example, 20 milligrams Synephrine is supposed to be a fairly decent fat loss compound. So we set up a human subject study and tested all the parameters of fat loss using 1) 25 mgs of pure Synephrine then, 2) 50 mgs of pure Synephrine HCl (hydrochloride) and finally, 3) 200 mgs of pure Synephrine HCl. Even when these high amounts of pure Synephrine were stabilized with HCl and bound to a polymer-lipid based delivery system, thermogenisis was not induced. Furthermore, energy, heart rate and oxygen uptake did not increase nor were any other markers of fat loss apparent! We were about to give up on Synephrine until I came up with one last creative effort to get this compound to work. We turned to several molecular modifications of Synephrine to see if this scientific approach would make this compound an effective fat loss agent. I must admit that there was a great deal of apprehension because generally speaking, if an ingredient doesn't work to begin with, it normally doesn't work no matter what you do to the chemical structure. The answer to the Synephrine challenge was to chemically engineer Methyl Synephrine. To our delight Methyl Synephrine didn't make your heart race or give you anxiety. After perfecting Methyl Synephrine, human subjects were excited about its effectiveness and our scientific team was even more excited knowing how well beta andrenergic agonists stack with alpha antagonists in regard to fat loss.

With Yohimbine HCl, 11-hydroxy Yohimbine, alpha-Yohimbine and Methyl Synephrine VPX could have easily stopped here and delivered the best fat stacked together have a significant synergistic effect to cut fat. Therefore, we theorized that combining caffeine with Methyl Synephrine would exert a similar fat loss effect. More importantly, we theorized that we could create a combination with a more scientifically hip: Caffeine-Methyl Synephrine-Yohimbine HCl, 11-hydroxy Yohimbine, alpha-Yohimbine stack. And, human subjects (including myself) confirmed that our theory was correct! All my staff and I can say is that this combination rocks, period!

Naturally Occurring “Designer” Fat Loss Compounds
Phenylethylamine (PEA) processes the unique capacity to increase metabolism by stimulating your thyroid gland and inducing thermogenisis to burn fat while eliciting the mild euphoria of eating a 1000 chocolate bars. So imagine if you could take PEA and make it 40 to 60 times more effective? Meltdown may give you the buzz of 40,000 fat and calorie free chocolate bars while melting fat off faster than a blow torch! Therefore, it was now time to add our new breakthrough fat loss compounds called, R-ß-M-PEA (R-ß-Methylphenylethylamine) and n-Methyl-ß-PEA (n-Methyl-ß-Phenylethylamine). We originally began working with ordinary ß-PEA and ß-PEA HCl but found these compounds to have far too many limitations. First, they were metabolized far too quickly and secondly, their ability to cross the blood brain barrier was weak and could, therefore, be astronomically improved up to 40 to 60 times by using the R-ß-M-PEA and n-Methyl-ß-PEA versions! This is mind boggling considering that most consumers and other supplement companies are already satisfied with ordinary PEA. But remember, I’m staking my entire career and reputation on my guarantee that Meltdown® is the most profound scientific fat loss innovation of the decade!

High Powered Hordenine™
It is commonly known to skilled biochemists that the kinetics of any version of PEA can be extended when combined with an MAO inhibitor. However, I was highly disappointed with lack of MAO inhibiting capacity of Hordenine and Hordenine HCL. We needed this compound to kick butt for two major reasons. To achieve the desired MOA inhibition effect, we again had to alter the basic chemical structure to create a super type of High Powered Hordenine. Unlike straight Hordenine or Hordenine HCl, this special Hordenine had to be a potent MAO inhibitor to prevent PEA from being metabolized by the monoamine oxidase (MAO) enzyme. Blocking MAO would increase the duration of action of our brilliant R-ß-M-PEA and n-Methyl-ß-PEA inventions and permit easy transport across the blood brain barrier. In medicine this is called increasing the pharmacokinetic value. This would allow R-ß-M-PEA and n-Methyl-ß-PEA - two of the most potent legal designer fat loss compounds - to become even more efficacious.

Of equal importance, adding the appropriate functional group to the chemical structure would also ramp up Hordenine’s intrinsic andrenergic fat burning capacity. So, after attempting to stabilize Synephrine with HCl and failing at hydroxylation to make it more soluble as was accomplished with 11 Hydroxy Yohimbine, we finally arrived at adding a Methyl functional group to Hordenine thus giving birth to “Undisputed King of all MOA Inhibitors called, Methyl Hordenine AKA High Powered Hordenine! - not to mention that Methyl Hordenine and Methyl Synephrine are an outstanding beta adrenergic agonist fat loss stack that works synergistically with the triple Yohimbine alpha 1 and alpha 2 andrenergic antagonists. And, we are all well aware from that Caffeine further enhances the effect of andrenergic agonists like Methyl Hordenine/Methyl Synephrine and Yohimbine. And, our Methyl Hordenine innovation produced effects beyond our wildest imagination with real human subjects when combined with R-ß-M-PEA and n-Methyl-ß-PEA and the other above-mentioned compounds in Meltdown. This resulted in a super clean mild “X” buzz with unprecedented mental acuity that lasted for hours and extended thermogenisis, carb Craving Control® and other markers of fat loss.

Methyl Synephrine AKA Super Synephrine™
Caution: Synephrine does not work! I hate to burst your bubble but Synephrine and Synephrine HCl are as useless as a screen door on a submarine. However, Methyl Synephrine is an off the chain version of Synephrine. This adrenergic amine robustly accelerates fat metabolism and thermogenisis to simultaneously speed up the fat burning process. Methyl Synephrine has mild stimulating properties on the central nervous system which is highly desirable because you get ultimate fat burning properties without the racing heart and anxiety. This functions to increase the metabolic rate without affecting heart rate or blood pressure. Synephrine releases epinephrine and norepinephrine primarily in the beta-3 receptor sites in adipose (fat) tissue. Stimulation of the beta-3 receptor sites brings forth lipolysis meaning it stimulates fat metabolism. Another distinctive physiological property of Methyl Synephrine is its role as an Alpha-1 adrenergic agonist which plays a major part in the metabolization and destruction of body fat by freeing up stored body fat and allowing you to burn it for energy (lipolysis). Acting on both Alpha 1 and Beta 3 receptors to induce fat loss is why Methyl Synephrine will earn its reputation as a powerful lipolytic agent in scientific circles when is released to the general public.

Further, adding a functional group to the chemical structure ramped up Synephrine’s Beta 3 intrinsic fat burning capacity. So, after trying stabilization of Synephrine with HCl and failing at hydroxylation, we finally arrived at adding a Methyl functional group to Synephrine thus giving birth to Methyl Synephrine This compound was so impressive that we trade marked it as Super Synephrine™! And, of course our Super Methyl Synephrine produced effects beyond our wildest imagination with real human subjects when combined with R-ß-M-PEA and n-Methyl-ß-PEA and the other above-mentioned compounds in Meltdown.

Meltdown Fat Assault Matrix Declares Death to Fat Cells
! Tetradecylthioacetic acid (TTA) is referred to in science as having pleiotropic properties meaning that it produces many effects from a single compound. As you probably expected, these effects all relate to monster fat loss! In fact, the biological responses to TTA in regard to fat loss are so profound that it is hard to believe a fat burning agent of this diverse nature actually exists. Guess where fat is burned? It’s burned in the mitochondria of the muscle cell and TTA induces mitochondrial proliferation (increases the number of mitochondria in the cell). The more mitochondria contained within a muscle cell, the greater your capacity to burn fat. So it’s no wonder that another biological response to TTA is increased catabolism of fatty acids. You have probably heard the word catabolism before in reference to destroying muscle tissue which is not good; however, in the case of TTA we refer to catabolism in regard to destroying fat which is highly desired! Meltdown does NOT contain TTA. About 10 years ago I was tagged with the name “Supplement Guru” for a reason and that was because I am somewhat of a freak in the field of research and development science and also overly enthusiastic about bringing you new supplement innovations that have physique-altering properties. Therefore, although very powerful, I wasn’t going to use just TTA. Instead, the goal was to turn the heat up a several hundred percent in Meltdown with M-TTA or Methyl TTA. M-TTA also promotes anti-adiposity meaning it prevents you from storing fat along with improving insulin sensitivity. If you read my Zero Impact Diet book or read the newest N.O. Shotgun article, you would know the importance of insulin sensitivity in building muscle and annihilating body fat. Other biological aspects of M-TTA are, reduced proliferation and apoptosis (death) to fat cells.

Comparing other Fat Burners to Meltdown is Like Comparing a Tricycle to a Stealth Bomber
Meltdown is the world’s most scientifically sophisticated advanced fat burner. Meltdown is powered by a pharmaceutically inspired polymer based lipid delivery system called PolyLipid. This “steady state” technology delivers both rapid and sustained controlled-release of the powerful active Meltdown compounds. VPX is the father of liquid delivered fat burners in the nutritional industry and to date has engineered and sold more liquid delivered fat burning ingredients than all other companies combined! You won’t catch VPX doing any mindless “capsule within a capsule” hocus pocus nonsense. PolyLipid Delivery is advanced and authentic pharmaceutical science that dramatically improves the pharmacokinetics of fat burning compounds.

You will only find the pure R-ß-M-PEA and n-Methyl-ß-PEA powerhouse versions of PEA in Meltdown. Well, guess what? There are many other really cool fat loss ingredients in Meltdown like the bio-molecularly engineered, CCK-8, and pure cAMP. However, unfortunately, I’m out of time and this magazine was supposed to go to print today and here I’m spilling my heart and soul out to you about the greatest fat loss invention of the 21st Century.

Meltdown Science combines the synergistic fat burning power of beta andrenergic agonists (MethylSynephrine) and alpha andrenergic antagonists (Yohimbine HCl, alpha-Yohimbine and 11-Hydroxy Yohimbine). In simpler terms it activates fat burning mechanisms in your body while simultaneously blocking the internal biochemistry that prevents you from burning fat by guarding one of the body’s key fat burning hormones called Norepinephrine (NE). When fat burning is both promoted and protected at the same time we call this effect “synergistic”. So, instead of 9 (activation factor) + 8 (protection factor) equaling 17 on the fat burning scale, this synergistic combination has a geometric effect of 72!

The powerful fat loss agent, 11-Hydroxy Yohimbine is of great interest here because regular Yohimbine yields a roughly 32% increase in the fat burning hormone, NE. Compare this to 11-Hydroxy Yohimbine that yields an even more impressive research proven 56% increase in the potent fat burning hormone, NE. We are only now just studying how the combination of the other Yohimbine compounds in Meltdown work in concert to increase NE even further. With the combined effect of alpha-Yohimbine and 11-hydroxy Yohimbine contained in Meltdown blocking both alpha-1 and alpha-2 receptors, my hypothesis is that we are looking at a 81%+ increase in NE!

This is only the tip of a large scientific iceberg Meltdown!

Synergistic Tri-Matrix™
11-hyrdoxy Yohimbine is the active metabolite of Yohimbine. Research indicates that 11-hydroxy Yohimbine has a potent alpha-2 adrenergic receptor affinity that significantly increases lipid metabolism. 11-Hydroxy Yohimbine exhibits a 10 fold increase in the binding ability to alpha-2 adrenergic receptors. The half-life of 11-hydroxy Yohimbine is approximately 8 to 11 hours compared to Yohimbine’s two hour half-life. 11-Hydroxy Yohimbine offers definite advantage over Yohimbine in alpha-2 adrenergic receptors binding affinity and the longer half life in blood. The body converts Yohimbine to 11-hydroxy metabolite in the liver.
Consequently, it is Meltdown’s unique Yohimbine Tri-Matrix that works synergistically to increase unmatched norepinephrine- induced fat burning in both potency and duration of action.

Methyl Synephrine (MS) -- as previously mentioned MS is a beta-3 AA. The magnificence of a beta-3 Andrenergic Agonist lies in it’s ability to burn fat with out causing anxiety.

The active Methyl PEA isomer, R-beta Methylphenylehtylamine - found botanically in nature and found also in chocolate, is a simpler form called PEA has been called the love compound. Think of Meltdown’s R-beta Methylphenylehtylamine as the love compound in overdrive dramatically enhancing the sexual experience and many other aspects of fat loss and is trademarked by VPX as Craving Control® and Mind Control Matrix™ for its potent ability to shut down appetite and eliminate carbohydrate cravings.

MTTA is another really impressive research proven compound that causes apoptosis or systematic death to fat cells.

Meltdown is also designed to increase mental clarity and mood with minimal jitteriness while burning fat at an unprecedented rate.

Other Ingredients
Bioliquid™ PolyLipid™ (Polymer-Lipid Based) Delivery System: Contains One Or More Of The Following: Super Refined Sesamum Indicum (Sesame) Seed Oil, Propylene Glycol Fatty Acid Ester, Safflower Oil, Sunflower Oil, Purified Water, Gelatin, Titanium Dioxide.

Directions
As a dietary supplement, the maximum recommended serving is three Meltdown® capsules. However, begin use with one to two capsules daily to assess tolerance. Never exceed more than three total capsules daily or in a single dose.

Warnings
Not for use by individuals under the age of 18 years. Do not use if pregnant or nursing. Always consult a licensed practitioner prior to starting any diet and/or exercise program. Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, heart disease, thyroid disease, diabetes, high blood pressure, depression or other psychiatric condition, glaucoma, difficulty in urinating, prostate enlargement, or seizure disorder, or if you are using a monoamine oxidase inhibitor (MAOI) or any other dietary supplement, prescription drug, or over-the-counter drug containing ephedrine, pseudoephedrine, or phenylpropanolamine (ingredients found in certain allergy, asthma, cough or cold, and weight control products).

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Customer reviews:

Author: Gast 09.09.2011

Bei meinem letzten Besuch in NYC,habe ich mir eine Dose mitgenommen. Hab die Teile durchgehend genommen,on - off schema beachtet und muss sagen, die Teile sind GUT!!! Ob morgens zum Wach werden oder als Trainingsbooster,man wird nicht enttäuchst. Die Wirkungszeit hat mir besonders gut gefallen. Da ich selbst unterschiedliche Produkte bis dato getestet habe möchte ich nicht sagen, dass die Meltdown´s die besten sind...wohl aber ihr Geld wert sind. Ideal zum Abspecken,definieren und als Trainingsbooster einsatz. PS. Ich habe die Teile einmal auf leeren Magen genommen und muss sagen, die hauen rein! Lieber etwas vorher essen. Ich habe die Einnahme von 2 Caps pro Tag nie überschreiten müssen, im gegenteil bei der Einnahme nach 17:00 Uhr war nichts mit einschlafen um 00:00.

Author: Gast 15.08.2011

Hi! Top Produkt! Wollte mir gerade meine 2te Dose bestellen und sehe dasses nicht verfügbar ist! Wisst ihr schon wanns wieder rein kommt? Oder muss ich mich nach ner Alternative umsehen? Danke für die Info! Gruß

Author: Gast 22.06.2011

Wann wird Meltdown wieder erhältlich sein?

Author: Gast 02.05.2011

Top Produkt ! Wann kommt Meltdown wieder rein ?

Author: Gast 21.04.2011

Habe Meltdown zur unterstützung einer strengen Definitionsdiät verwendet; 3 Kapseln am morgen auf leeren Magen und dann 20-30 Minuten mittelintensives Cardio, es ist bei dem Produkt halt oberste Priorität, dass man es auf komplett leeren Magen nimmt und danach auch ca 2 Stunden auf Insulin produzierende Nahrung verzichten (Empfehlung: entweder die Diät mit einem Cortisolblocker oder Aminokapseln unterstützen, sonst geht ein Teil der Muskelmasse flöten) Die Diätbasierte auf der Idee einer 25%igen Kalorienreduktion und einer Neuverteilung der Kalorien im Verhältnis 25(KH):50(EW):25(Fett) wobei ich bei jeder zweiten Mahlzeit den Kohlenhydratanteil auf Fett umrechnete (damit sich mein Körper zusätzlich auf Lipide als Energielieferant einstellen konnte) Verzichtet hab ich während der Diät auf große Mengen gesättigter Fettsäuren, Salz und auf jegliche Art von Zucker als Kohlenhydrat (kein Industriezucker, aber genausowenig Milchzucker und Fruchtzucker) jeder 4te Tag war dann ein Aufladetag, an dem ich mich eher wieder normal ernährte (normales Verhältnis, trotzdem kein Junkfood etc) um eine Verlangsamung des Stoffwechsels zu verhindern, an diesem Tag empfehle ich zwei vielseitige Obstmahlzeiten! Ich habe die Diät jetzt 21 Tage durchgezogen und bin mit dem Ergebnis ziemlich zufrieden, natürlich ist es nicht immer leicht, jede einzelne Mahlzeit mit der Grammwage abzuwiegen und die ganze Zeit mit dem Taschenrechner rumzulaufen um jedes einzelne Kalorien genau miteinzuberechnen, aber wer aus seiner Definitionsdiät das Beste rausholen will, muss dieses Prozedere über sich ergehen lassen... Meine Ergebnisse sprechen für sich: 5,5 kg runter auf 80 kg und KFA um fast 4% auf insgesamt 7% gesenkt, ich bin am kompletten Körper viel gezeichneter geworden, noch nie zuvor kamen bei mir derartige Konturen raus, Meltdown hat mich dabei stark unterstützt, vor allem das morgentliche Jogging auf leeren Magen hätte ich ohne den Yohimbinkick kaum überstanden! 5 Sterne

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