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Histidin

Histidin wurde 1896 aus Protein erstmals isoliert, die Struktur wurde durch chemische Synthese 1911 geklärt. Die Seitenketten von Histidin können sowohl sauer als auch basisch sein. Histidin kann aus der Hydrolyse vieler Proteine gewonnen werden, es gilt für Erwachsene als bedingt essentiell, für Kinder und für Menschen mit einem chronischen Nierenversagen jedoch als essentiell.
Histidin ist an der Synthese von Hämoglobin (Blutfarbstoff) in den roten Blutkörperchen beteiligt. Es wird als direkter Präkursor (Vorläuferstoff) für die Bildung von Histamin benötigt, das im Körper viele Funktionen hat. Es trägt beispielsweise zur Kontraktion von Darm, Uterus, Bronchien und Gefäßen bei und spielt eine Rolle bei allergischen Entzündungen. Histidin kann entzündungshemmend und antioxidativ wirken. Es kann bei entzündlichen Prozessen und Allergien freie Radikale abfangen und unschädlich machen. Histidin trägt zu einem gut funktionierenden Immunsystem bei, es unterstützt die Aktivität der weißen Blutkörperchen. Histidin ist weiter ein struktureller Teil verschiedener Enzyme, die am Stoffwechsel von Kohlenhydraten, Proteinen und Nukleinsäuren beteiligt sind. Es ist eine wichtige Quelle für Kohlenatome bei der Bildung von Purinen, die wiederum dazu beitragen, Nuklein- und Harnsäuren zu generieren. Histidin spielt außerdem bei der Aufnahme und Verwertung von Zink eine wichtige Rolle. Das Spurenelement Zink wird aus Fleisch im allgemeinen besser aufgenommen, da es dort häufig an Histidin gebunden vorkommt. Diese Verbindung erleichtert den Transport von Zink durch die Darmwand, und sie verbessert die anschließende Zinkverwertung.

Die Hauptlieferanten von Histidin
Histidin ist in pflanzlichen und tierischen Lebensmitteln enthalten, größere Mengen kommen in Fleisch und einigen Fischen vor.

Einige Histidin-reiche Lebensmittel enthalten in je 100 Gramm

Typische Gruppen für einen Mehrbedarf an Histidin
Bei einigen Belastungen und Krankheiten kann ein erhöhter Bedarf an Histidin bestehen. Ergänzungen können entsprechend dazu beitragen, die Versorgung zu verbessern.

bei Zinkmangel
bei bestimmten Formen der Anämie
bei rheumatoider Arthritis
bei stärkeren Stressbelastungen
bei chronischen Krankheiten, Verletzungen, Operationen
bei chronischem Nierenversagen.

Wenn Histidin im Körper fehlt
Bei Anämie kann eine zu geringe Versorgung mit Histidin die Bildung von Hämoglobin hemmen, bei bestimmten Formen der Krankheit kann die Ergänzung mit Histidin helfen. Bei rheumatoider Arthritis wird vermehrt Histidin abgebaut, das zeigt sich in geringen Histidin-Spiegeln im Blut und in der Gelenkflüssigkeit. Je niedriger die Spiegel dort sind, um so stärker sind die Schmerzen und Versteifungen. Ergänzungen mit Histidin können dazu beitragen, die Entzündungen und die Schmerzen zu senken, das gilt vor allem für ernste Erkrankungen.

Kann man Histidin überdosieren oder gibt es Nebenwirkungen?
Bei Dosen von bis zu vier Gramm Histidin täglich sind bei Erwachsenen keine Nebenwirkungen bekannt. Die Einnahme soll möglichst auf nüchternen Magen erfolgen, da Histidin dann besser absorbiert wird.

Der tägliche Bedarf an Histidin
Histidin kann in kleineren Mengen vom Körper selbst synthetisiert werden, es kann aus der Hydrolyse vieler Proteine gewonnen werden. 8 bis 12 Milligramm Histidin pro Kilogramm Körpergewicht werden empfohlen. Danach liegt der tägliche Bedarf von Erwachsenen etwa zwischen 0,5 und 1 Gramm Histidin.

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The Gigas Sports Ltd. Website serves solely as a source of information about the products offered. All of our products are considered as dietary supplements and not as medication. The usage of any of our products takes place at your own risk. None of our products should be used for treatment, cure, prevention or diagnosis of a medical condition. We do not give medical advice. Please consult a medical doctor before using any of our products. This is especially important, if you are currently treated because of an existing medical condition or if you take any medication or hormone preparations. Please read all instructions and product information carefully and do not exceed the stated dosage. If you have any questions concerning the usage or the action of a dietary supplement consult your healthcare professional or nutritionist. Please discontinue the usage and contact your medical doctor if any adverse reactions occur. All information about a product originates from the manufacturer, the product label or the specialized press. Store all nutritional supplements out of the range of children. We take no liability for any impairment of your health or any other damage. We are not liable wrong information or changes in product Ingredients. Gigas Sports Ltd. is not liable for promises or directions made by the manufacturer of a product.

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Histidin